Define DNA polymorphism. Briefly discuss various forms of DNA polymorphism

DNA polymorphism refers to the existence of genetic variation within a population at the level of DNA sequence.

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It signifies the presence of multiple forms or alleles of a gene or specific DNA sequence in a population.

Various forms of DNA polymorphism include:

  1. Single Nucleotide Polymorphisms (SNPs): SNPs are the most common type of DNA variation, involving a change in a single nucleotide base at a specific position in the DNA sequence. For example, a nucleotide position may interchange adenine (A) with guanine (G).
  2. Insertions and Deletions (Indels): These polymorphisms involve the insertion or deletion of a small number of nucleotides within the DNA sequence. Indels can range from a single base pair to several nucleotides.
  3. Copy Number Variations (CNVs): CNVs are larger segments of DNA (typically more than 1,000 base pairs) that are present in varying copy numbers among individuals. These variations can impact gene dosage and expression levels.
  4. Tandem Repeats: These are regions of DNA where short sequences of nucleotides are repeated multiple times. Variable Number Tandem Repeats (VNTRs) and Short Tandem Repeats (STRs) are examples. They contribute to genetic diversity and are used in DNA fingerprinting and forensic analysis.
  5. Inversions and Translocations: These structural variations involve rearrangements of larger segments of DNA. Inversions flip a segment of DNA within a chromosome, while translocations involve the movement of a segment from one chromosome to another.

DNA polymorphisms serve as valuable markers for studying genetic diversity, population genetics, evolutionary relationships, and disease susceptibility among individuals and populations. They are essential in genetic research, diagnostics, forensics, and understanding the inheritance of traits and diseases.